Description
Ophiorrhiza pumila, a fast-growing herbaceous plant from the Rubiaceae family, has emerged as a model plant for the study of monoterpene indole alkaloids (MIAs) biosynthesis and regulation, and a sustainable source of camptothecin. Camptothecin, a strictosidinederived molecule and one of the most potent anticancer MIAs, is the precursor for the commercial synthesis of topotecan and irinotecan.
- SUMMARY
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Published journals
Nature Communications
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Publish date
2021.01
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Sequence Method
PacBio RS II, PacBio Sequel, Illumina HiSeq
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Assembly
Opu_r1.4
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Assembly Method
Canu v. 1.6
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Genome Size
440.319 Mb
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Genome Coverage
308x
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Scaffolds
13
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Contigs
36
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N50
18486819
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Bioproject
PRJDB8685
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GCA Number
GCA_016586305.1
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Data
https://ftp.ncbi.nlm.nih.gov/genomes/all/GCA/016/586/305/GCA_016586305.1_Opu_r1.4/
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Reference url
Reference
Rai, A., Hirakawa, H., Nakabayashi, R., Kikuchi, S., Hayashi, K., Rai, M., Tsugawa, H., Nakaya, T., Mori, T., Nagasaki, H., Fukushi, R., Kusuya, Y., Takahashi, H., Uchiyama, H., Toyoda, A., Hikosaka, S., Goto, E., Saito, K., & Yamazaki, M. (2021). Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis. Nature communications, 12(1), 405. https://doi.org/10.1038/s41467-020-20508-2